An Efficient and Solvent-Free Synthesis of Mixed Ortho Esters
Kelly L. Cosgrove, Ross P. McGeary*
*School of Molecular and Microbial Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia, Email: r.mcgearyuq.edu.au
K. L. Cosgrove, R. P. McGeary, Synlett, 2008, 2425-2428.
DOI: 10.1055/s-2008-1078215
Abstract
Primary, secondary and electron-deficient tertiary alcohols react rapidly with ketene dimethyl acetal to form mixed ortho esters, without catalysts and under solvent-free conditions. 1,2-Diols yield bis(mixed ortho esters), rather than cyclic ortho esters.
see article for more examples
K. L. Cosgrove, R. P. McGeary, Synlett, 2009, 1749-1752.
Key Words
ortho esters, ketene dimethyl acetal, alcohols, cyanohydrins, 1,2-diols
ID: J60-Y2008-2730