A New Family of Tunable Indolylphosphine Ligands by One-Pot Assembly and Their Applications in Suzuki-Miyaura Coupling of Aryl Chlorides
Chau Ming So, Chung Chiu Yeung, Chak Po Lau, and Fuk Yee Kwong*
*Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, Email: bcfykinet.polyu.edu.hk
C. M. So, C. C. Yeung, C. P. Lau, F. Y. Kwong, J. Org. Chem., 2008, 73, 7803-7806.
DOI: 10.1021/jo801544w (free Supporting Information)
Highly diversificated indolylphosphine ligands can be easily accessed by a simple one-pot assembly from commercially available indoles, acid chlorides, and chlorophosphines. The application of this ligand array in palladium-catalyzed Suzuki-Miyaura coupling reaction of aryl chlorides with arylboronic acids allows catalyst loading down to 0.01 mol% of Pd.
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C. M. So, C. P. Lau, F. Y. Kwong, Org. Lett., 2007, 9, 2795-2798.