Facile Preparation of α-Aryl Nitriles by Direct Cyanation of Alcohols with TMSCN Under the Catalysis of InX3
Gang Chen, Zheng Wang, Jiang Wu and Kuiling Ding*
*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China, Email: kdingmail.sioc.ac.cn
G. Chen, Z. Wang, J. Wu, K. Ding, Org. Lett., 2008, 10, 4573-4576.
DOI: 10.1021/ol801812a (free Supporting Information)
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A direct cyanation of benzylic alcohols with TMSCN under the catalysis of 5-10 mol % of InBr3 allows the synthesis of the corresponding nitriles in short reaction time with good yields.
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