Organic Chemistry Portal

Abstracts

Search:

Facile Preparation of α-Aryl Nitriles by Direct Cyanation of Alcohols with TMSCN Under the Catalysis of InX3

Gang Chen, Zheng Wang, Jiang Wu and Kuiling Ding*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China, Email: kdingmail.sioc.ac.cn

G. Chen, Z. Wang, J. Wu, K. Ding, Org. Lett., 2008, 10, 4573-4576.

DOI: 10.1021/ol801812a (free Supporting Information)


see article for more reactions

Abstract

A direct cyanation of benzylic alcohols with TMSCN under the catalysis of 5-10 mol % of InBr3 allows the synthesis of the corresponding nitriles in short reaction time with good yields.

see article for more examples



Key Words

Cyanation


ID: J54-Y2008-2970