Microwave-Assisted Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with H-Phosphonate Diesters

Marcin Kalek, Asraa Ziadi and Jacek Stawinski*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, Email: jsorgan.su.se

M. Kalek, A. Ziadi, J. Stawinski, Org. Lett., 2008, 10, 4637-4640.

DOI: 10.1021/ol801935r

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Abstract

Using a prevalent palladium catalyst, Pd(PPh₃)₄, a quantitative cross-coupling of various H-phosphonate diesters with aryl and vinyl halides was achieved in less than 10 min under microwave irradiation. The reactions occurred with retention of configuration at the phosphorus center and in the vinyl moiety.

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Palladium(0)-Catalyzed Benzylation of H-Phosphonate Diesters: An Efficient Entry to Benzylphosphonates

G. Lavéna, J. Stawinski, Synlett, 2009, 225-228.

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Key Words

phosphonates, microwave synthesis

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ID: J54-Y2008-3050