Nickel-Catalyzed Enantioselective Alkylative Coupling of Alkynes and Aldehydes: Synthesis of Chiral Allylic Alcohols with Tetrasubstituted Olefins
Yun Yang, Shou-Fei Zhu, Chang-Yue Zhou and Qi-Lin Zhou*
*State Key Laboratory and Institute of Elemento-organic
Chemistry, Nankai University, Tianjin 300071, China, Email: qlzhou
nankai.edu.cn
Y. Yang, S.-F. Zhu, C.-Y. Zhou, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 130, 14052-14053.
DOI: 10.1021/ja805296k
Abstract
A highly efficient nickel-catalyzed asymmetric alkylative coupling of alkynes, aldehydes, and dimethylzinc in the presence of bulky spirobiindane phosphoramidite ligands affords allylic alcohols with tetrasubstituted olefin functionalities in high yields, high regioselectivities, and excellent enantioselectivities
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Key Words
ID: J48-Y2008-3060
