Enyne Cross-Metathesis with Strained, Geminally-Substituted Alkenes: Direct Access to Highly Substituted 1,3-Dienes
Daniel A. Clark, Brenda S. Basile, William S. Karnofel and Steven T. Diver*
*Department of Chemistry, University at Buffalo, The State
University of New York, Amherst, New York 14260, Email: diver
buffalo.edu
D. A. Clark, B. S. Basile, W. S. Karnofel, S. T. Diver, Org. Lett., 2008, 10, 4927-4929.
DOI: 10.1021/ol802007q
Abstract
Angle strain in methylene cyclobutane drives a cross-enyne metathesis with 1-alkynes, giving 1,1,3-trisubstituted 1,3-dienes in good isolated yields. An extensive survey of Grubbs' second-generation catalysts led to optimized reaction conditions.
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Key Words
Enyne Metathesis, Cyclobutanes
ID: J54-Y2008-3280
