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Synthesis of Medicinally Interesting Polyfluoro Ketones via Perfluoroalkyl Lithium Reagents

Christoforos G. Kokotos, Constantinos Baskakis and George Kokotos*

*Laboratory of Organic Chemistry, Department of Chemistry, University of Athens, Panepistimiopolis, Athens 15771, Greece, Email: gkokotoschem.uoa.gr

C. G. Kokotos, C. Baskakis, G. Kokotos, J. Org. Chem., 2008, 73, 8623-2626.

DOI: 10.1021/jo801469x (free Supporting Information)


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Abstract

The addition of (pentafluoroethyl)- and (heptafluoropropyl)lithium to Weinreb and morpholine amides led to polyfluoro ketones in high to quantitative yields in short reaction times. The methodology can provide inhibitors for various lipolytic enzymes, including phospholipase A2.

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Key Words

Perfluoroalkylation, Acylation


ID: J42-Y2008-3330