Asymmetric Carbonyl-Ene Reaction Catalyzed by Chiral N,N′-Dioxide-Nickel(II) Complex: Remarkably Broad Substrate Scope
Ke Zheng, Jian Shi, Xiaohua Liu and Xiaoming Feng*
*Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, P. R. China, Email: xmfengscu.edu.ch
K. Zheng, J. Shi, X. Liu, X. Feng, J. Am. Chem. Soc., 2008, 130, 15770-15771.
DOI: 10.1021/ja808023y (free Supporting Information)
A novel nickel(II)-N,N′-dioxide complex facilitated the asymmetric synthesis of biologically interesting α-hydroxy carbonyl compounds under mild conditions by a highly enantioselective carbonyl-ene reactions of glyoxal derivatives with various alkenes. Various aromatic, aliphatic, and heteroaromatic glyoxal derivatives, as well as glyoxylate, were tolerated.
see article for more examples