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An Efficient Method for the Selective Iodination of α,β-Unsaturated Ketones

Zihua Wang, Guodong Yin, Jing Qin, Meng Gao, Liping Cao, Anxin Wu*

*Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China, Email: chwuaxmail.ccnu.edu.cn

Z. Wang, G. Yin, J. Qin, M. Gao, L. Cao, A. Wu, Synthesis, 2008, 3565-3568.

DOI: 10.1055/s-0028-1083200


Abstract

An efficient approach to α,β-unsaturated α′-iodo ketones directly from α,β-unsaturated ketones by selective iodination at the α′-position in the presence of copper(II) oxide/iodine offers high yields, short reaction times, inexpensive reagents, mild reaction conditions, ease of manipulation, and the formation of cleaner products.

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Key Words

iodination, aldol condensation, α,β-unsaturated ketones, α,β-unsaturated α′-iodo ketones, self-sorting


ID: J66-Y2008-3470

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