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Highly Chemoselective Reductive Amination of Carbonyl Compounds Promoted by InCl3/Et3SiH/MeOH System

On-Yi Lee, Ka-Lun Law, Chun-Yu Ho and Dan Yang*

*Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's republic of China, Email: yangdanhku.hk

O.-Y. Lee, K.-L. Law, C.-Y. Ho, D. Yang, J. Org. Chem., 2008, 73, 8829-8837.

DOI: 10.1021/jo8016082 (free Supporting Information)


Abstract

Reductive amination of aldehydes and ketones with the InCl3/Et3SiH/MeOH system is highly chemoselective and can be applied to various cyclic, acyclic, aromatic, and aliphatic amines. Functionalities including ester, hydroxyl, carboxylic acid, and olefin are tolerated.

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Key Words

Reductive Amination, Allylic Amines, Triethylsilane


ID: J42-Y2008-3490