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Oxidative Pd(II)-Catalyzed C-H Bond Amination to Carbazole at Ambient Temperature

James A. Jordan-Hore, Carin C. C. Johansson, Moises Gulias, Elizabeth M. Beck and Matthew J. Gaunt*

*Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, U.K., Email: mjg32cam.ac.uk

J. A. Jordan-Hore, C. C. C. Johansson, M. Gulias, E. M. Beck, M. J. Gaunt, J. Am. Chem. Soc., 2008, 130, 16184-16186.

DOI: 10.1021/ja806543s (free Supporting Information)


Abstract

A Pd(II)-catalyzed C-H bond amination reaction operates under extremely mild conditions and produces carbazole products in good to excellent yields. Carbazoles possessing complex molecular architecture can also be formed using this reaction, highlighting its potential in natural product synthesis applications.

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Key Words

carbazoles, phenyliodonium diacetate


ID: J48-Y2008-3550