Micellar Catalysis of Suzuki-Miyaura Cross-Couplings with Heteroaromatics in Water
Bruce H. Lipshutz* and Alexander R. Abela
*Department of Chemistry & Biochemistry, University of
California, Santa Barbara, California 93106, Email: lipshutz
chem.ucsb.edu
B. H. Lipshutz, A. R. Abela, Org. Lett., 2008, 10, 5329-5332.
DOI: 10.1021/ol801712e
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Abstract
Pd-catalyzed couplings of several (hetero)aromatic halides with (hetero)aromatic boronic acids can be conducted under mild conditions in pure water using commercially available Pd catalysts and PTS, a nanomicelle-forming amphiphile.
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Room-Temperature Suzuki-Miyaura Couplings in Water Facilitated by Nonionic Amphiphiles
B. H. Lipshutz, T. B. Petersen, A. R. Abela, Org. Lett., 2008, 10, 1333-1336.
Key Words
Suzuki Coupling, Heterobiaryls, Green Chemistry
ID: J54-Y2008-3560
