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Amide Synthesis from Alcohols and Amines by the Extrusion of Dihydrogen

Lars Ulrik NordstrÝm, Henning Vogt and Robert Madsen*

*Center for Sustainable and Green Chemistry, Department of Chemistry, Building 201, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark, Email:

L. U. NordstrÝm, H. Vogt, R. Madsen, J. Am. Chem. Soc., 2008, 130, 17672-17673.

DOI: 10.1021/ja808129p (free Supporting Information)


A simple ruthenium catalyst mediates a direct coupling between an alcohol and an amine with the liberation of two molecules of dihydrogen. The active catalyst is generated in situ from an easily available ruthenium complex, an N-heterocyclic carbene and a phosphine. The reaction allows primary alcohols to be coupled with primary alkylamines to afford secondary amides in good yields.

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Key Words

Amides, Oxidation

ID: J48-Y2008-3870