Efficient α-Methylenation of Carbonyl Compounds in Ionic Liquids at Room Temperature

Juliana A. Vale, Daniel F. Zanchetta, Paulo J. S. Moran, J. Augusto R. Rodrigues*

*Institute of Chemistry, University of Campinas, UNICAMP, P.O. Box 6154, 13084-971 Campinas, SP, Brazil, Email: jaugustoiqm.unicamp.br

J. A. Vale, D. F. Zanchetta, P. J. S. Moran, J. A. R. Rodrigues, Synlett, 2009, 75-78.

DOI: 10.1055/s-0028-1087389

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Abstract

The application of the 1-butyl-3-methylimidazolium-based ionic liquid [BMIM][NTf₂] as solvent enabled clean α-methylenations of carbonyl compounds in a short time and good yields. This ionic liquid was reused without affecting the reaction rates or yields over seven runs.

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Key Words

ionic liquids, methylenation, enones, carbonyl compounds, organocatalysis

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ID: J60-Y2009-0120