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Palladium-Indolylphosphine-Catalyzed Hiyama Cross-Coupling of Aryl Mesylates

Chau Ming So, Hang Wai Lee, Chak Po Lau and Fuk Yee Kwong*

*Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong, Email: bcfykinet.polyu.edu.hk

C. M. So, H. W. Lee, C. P. Lau, F. Y. Kwong, Org. Lett., 2009, 11, 317-320.

DOI: 10.1021/ol802493z (free Supporting Information)


Abstract

Aryl mesylates are found to be applicable as electrophiles in organosilicon-mediated coupling reactions. The catalyst system comprising Pd(OAc)2 and CM-phos as ligand is highly effective in catalyzing Hiyama cross-coupling of various aryl and heteroaryl mesylates. The presence of acetic acid efficiently suppresses the mesylate decomposition.

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Suzuki-Miyaura Coupling of Aryl Tosylates Catalyzed by an Array of Indolyl Phosphine-Palladium Catalysts

C. M. So, C. P. Lau, A. S. C. Chan, F. Y. Kwong, J. Org. Chem., 2008, 73, 7731-7734.

Suzuki-Miyaura Coupling of Aryl Tosylates Catalyzed by an Array of Indolyl Phosphine-Palladium Catalysts

C. M. So, C. P. Lau, A. S. C. Chan, F. Y. Kwong, J. Org. Chem., 2008, 73, 7731-7734.


Key Words

Hiyama Coupling, Biaryls


ID: J54-Y2009-0210