Palladium(0)-Catalyzed Benzylation of H-Phosphonate Diesters: An Efficient Entry to Benzylphosphonates

Gaston Lavéna, Jacek Stawinski*

*Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden, Email: jsorgan.su.se

G. Lavéna, J. Stawinski, Synlett, 2009, 225-228.

DOI: 10.1055/s-0028-1087522

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Abstract

An efficient method allows the synthesis of benzylphosphonate diesters via a palladium(0)-catalyzed cross-coupling reaction between benzyl halides and H-phosphonate diesters, using Pd(OAc)₂ as a palladium source and Xantphos as a supporting ligand.

see article for more examples

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Microwave-Assisted Palladium-Catalyzed Cross-Coupling of Aryl and Vinyl Halides with H-Phosphonate Diesters

M. Kalek, A. Ziadi, J. Stawinski, Org. Lett., 2008, 10, 4637-4640.

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Key Words

phosphonates, benzylphosphonates, palladium cross-coupling, H-phosphonates, C-phosphonates

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ID: J60-Y2009-0270