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Iridium-Catalyzed Asymmetric Hydrogenation of Cyclic Enamines

Guo-Hua Hou, Jian-Hua Xie, Pu-Cha Yan and Qi-Lin Zhou*

*State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China, Email:

G.-H. Hou, J.-H. Xie, P.-C. Yan, Q.-L. Zhou, J. Am. Chem. Soc., 2009, 131, 1366-1367.

DOI: 10.1021/ja808358r (free Supporting Information)


A highly enantioselective iridium-catalyzed hydrogenation of cyclic enamines is efficient method for the synthesis of optically active cyclic tertiary amines including natural product crispine A.

see article for more examples

Synthesis of Crispine A

Iridium-Catalyzed Enantioselective Hydrogenation of α,β-Unsaturated Carboxylic Acids

S. Li, S.-F. Zhu, C.-M. Zhang, S. Song, Q.-L. Zhou, J. Am. Chem. Soc., 2008, 130, 8584-8585.

Key Words

Pyrrolidines, Hydrogen

ID: J48-Y2009-0370