2-Oxazol-5-ylethanones by Consecutive Three-Component Amidation-Coupling-Cycloisomerization (ACCI) Sequence
Eugen Merkul, Oliver Grotkopp, Thomas J. J. Müller*
*Institut für Organische Chemie und Makromolekulare Chemie, Lehrstuhl für Organische Chemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstraße 1, 40225 Düsseldorf, Germany, Email: ThomasJJ.Muelleruni-duesseldorf.de
E. Merkul, O. Grotkopp, T. J. J. Müller, Synthesis, 2009, 502-507.
DOI: 10.1055/s-0028-1083294
Abstract
Substituted oxazol-5-ylethanones can be synthesized in a consecutive three-component sequence starting with amidation of propargylamine with an acid chloride followed by cross-coupling with another acid chloride. Therefore, this diversity-oriented one-pot approach to substituted oxazoles can be considered as an amidation-coupling-cycloisomerization (ACCI) sequence.
see article for more examples
B. Willy, F. Rominger, T. J. J. Müller, Synthesis, 2008, 293-303.
Key Words
C-C coupling, catalysis, cycloisomerization, oxazoles
ID: J66-Y2009-0370