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Ligand-Free Palladium-Catalyzed Direct Arylation of Thiazoles at Low Catalyst Loadings

Julien Roger, Franc Pogan and Henri Doucet*

*Institut Sciences Chimiques de Rennes, UMR 6226 CNRS-Université de Rennes “Catalyse et Organometalliques”, Campus de Beaulieu, 35042 Rennes, France, Email:

J. Roger, F. Pogan, H. Doucet, J. Org. Chem., 2009, 74, 1179-1186.

DOI: 10.1021/jo802360d (free Supporting Information)


Ligand-free Pd(OAc)2 catalyzes very efficiently the direct arylation of thiazole derivatives under very low catalyst concentration. Reactions with activated aryl bromides can be performed employing as little as 0.1-0.001 mol % catalyst, whereas some strongly deactivated or highly congested aryl bromides only give disappointing results.

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ID: J42-Y2009-0390