A General Method for the Synthesis of Unsymmetrically Substituted Ureas via Palladium-Catalyzed Amidation
Brian J. Kotecki*, Dilinie P. Fernando, Anthony R. Haight and Kirill A. Lukin
*Abbott Laboratories, GPRD Process Research and Development,
Dept. R450, Bldg. R8, 1401 Sheridan Road, North Chicago, Illinois 60064, Email:
brian.kotecki
abbott.com
B. J. Kotecki, D. P. Fernando, A. R. Haight, K. A. Lukin, Org. Lett., 2009, 11, 947-950.
DOI: 10.1021/ol802931m
Abstract
Palladium-catalyzed amidation allows the preparation of unsymmetrically substituted ureas. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).
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Key Words
ID: J54-Y2009-0580
