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Copper/Diethyl Azodicarboxylate Mediated Regioselective Alkynylation of Unactivated Aliphatic Tertiary Methylamine with Terminal Alkyne

Xiaoliang Xu and Xiaonian Li*

*Institute of Industrial Catalysis, College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310032, People’s Republic of China, Email: xnlizjut.edu.cn

X. Xu, X. Li, Org. Lett., 2009, 11, 1027-1029.

DOI: 10.1021/ol802974b (free Supporting Information)


Abstract

Mediated by copper/diethyl azodicarboxylate, regioselective alkynylation of unactivated aliphatic tertiary methylamine with terminal alkyne was successfully established. The alkynylation reaction described here has the advantage of simple operation, mild reaction conditions, good to excellent yields, and no need to exclude air and moisture.

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Key Words

Propargylamines, Diethyl Azodicarboxylate


ID: J54-Y2009-0630