Microwave-Assisted Cu-Catalyzed Protodecarboxylation of Aromatic Carboxylic Acids
Lukas J. Goossen*, Filipe Manjolinho, Bilal A. Khan and Nuria Rodríguez
*Fachbereich Chemie, Technische Universitt Kaiserslautern,
Erwin-Schroedinger-Strasse, D-67663 Kaiserslautern, Germany, Email: goossen
chemie.uni-kl.de
L. J. Goossen, F. Manjolinho, B. A. Khan, N. Rodríguez, J. Org. Chem., 2009, 74, 2620-2623.
DOI: 10.1021/jo802628z (free Supporting Information)
Abstract
An effective protocol allows the smooth protodecarboxylation of diversely functionalized aromatic carboxylic acids within 5-15 min under microwave irradiation. In the presence of an inexpensive catalyst generated in situ from copper(I) oxide and 1,10-phenanthroline, even nonactivated benzoates were converted in high yields.
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Key Words
Decarboxylation, Microwave Synthesis
ID: J42-Y2009-0950
