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Efficient Intramolecular Hydroalkoxylation/Cyclization of Unactivated Alkenols Mediated by Lanthanide Triflate Ionic Liquids

Alma Dzudza and Tobin J. Marks*

*Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208-3113, Email: t-marksnorthwestern.edu

A. Dzudza, T. J. Marks, Org. Lett., 2009, 11, 1523-1526.

DOI: 10.1021/ol8029559 (free Supporting Information)


Abstract

Lanthanide triflates are efficient catalysts for the intramolecular Markovnikov-type hydroalkoxylation/cyclization of primary/secondary and aliphatic/aromatic hydroxyalkenes in room temperature ionic liquids (RTILs) to give five- and six-membered oxygen heterocycles in very good yields.

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Key Words

Tetrahydrofurans, Tetrahydropyrans, Ionic Liquids


ID: J54-Y2009-1010