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A Convenient Method for Converting Hydroxyacetophenones into Their Ethylene or Trimethylene Acetals

Fumiaki Ono, Hirotaka Takenaka, Toshikazu Fujikawa, Masaki Mori, Tsuneo Sato*

*Department of Life Science, Kurashiki University of Science and the Arts, Kurashiki 712-8505, Japan, Email: satochem.kusa.ac.jp

F. Ono, H. Takenaka, T. Fujikawa, M. Mori, T. Sato, Synthesis, 2009, 1318-1322.

DOI: 10.1055/s-0028-1088025


Abstract

Various types of hydroxyacetophenones are efficiently converted into the corresponding cyclic acetals in the presence of a diol, triisopropyl orthoformate, and a catalytic amount of cerium(III) trifluoromethanesulfonate under mild reaction conditions.

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Key Words

acetal, cyclic acetals, cerium(III) trifluoromethanesulfonate, hydroxyacetophenones, Lewis acid, protecting groups


ID: J66-Y2009-1230