Synthesis of Novel Chiral Phase-Transfer Catalysts and Their Application to Asymmetric Synthesis of α-Amino Acid Derivatives
Wei He, Quanjun Wang, Qiaofeng Wang, Bangle Zhang, Xiaoli Sun, Shengyong Zhang*
*Department of Chemistry, School of Pharmacy, The Fourth Military Medical University, 17 West Changle Road, 710032, Xi'an Shaanxi Province, P. R. of China, Email: syzhangfmmu.edu.cn
W. He, Q. Wang, Q. Wang, B. Zhang, X. Sun, S. Zhang, Synlett, 2009, 1311-1314.
DOI: 10.1055/s-0029-1216736
Abstract
Using a cinchonine-derived alkaloid catalyst, enantioselective alkylations of N-(diphenylmethylene) glycine tert-butyl ester were efficiently carried out with various alkyl halides to give products in high enantiomeric excess.
see article for more examples
Key Words
asymmetric catalysis, alkylation, O'Donnell Amino Acid Synthesis, phase-transfer catalysis, organocatalysis, cinchona alkaloids
ID: J60-Y2009-1570