Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides
Chong Han and Stephen L. Buchwald*
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu
C. Han, S. L. Buchwald, J. Am. Chem. Soc., 2009, 131, 7532-7533.
DOI: 10.1021/ja902046m (free Supporting Information)
A palladium catalyst composed of a biaryldialkylphosphine ligand effectively promotes the Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool.
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