Organic Chemistry Portal

Abstracts

Search:

Negishi Coupling of Secondary Alkylzinc Halides with Aryl Bromides and Chlorides

Chong Han and Stephen L. Buchwald*

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: sbuchwalmit.edu

C. Han, S. L. Buchwald, J. Am. Chem. Soc., 2009, 131, 7532-7533.

DOI: 10.1021/ja902046m (free Supporting Information)


Abstract

A palladium catalyst composed of a biaryldialkylphosphine ligand effectively promotes the Negishi coupling of secondary alkylzinc halides with a wide range of aryl bromides and activated aryl chlorides. The broad substrate scope and excellent ratio of the desired secondary to the undesired primary coupling product make this method a powerful and reliable tool.

see article for more examples



Key Words

Negishi Coupling, Arenes


ID: J48-Y2009-1720