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Acceleration of the Morita-Baylis-Hillman Reaction by a Simple Mixed Catalyst System

Alejandro Bugarin and Brian T. Connell*

*Department of Chemistry, Texas A&M University, P.O. Box 30012, College Station, Texas 77842-3012, Email: connellmail.chem.tamu.edu

A. Bugarin, B. T. Connell, J. Org. Chem., 2009, 74, 4638-4641.

DOI: 10.1021/jo900603w (free Supporting Information)


Abstract

By using equal, catalytic amounts of 4-dimethylaminopyridine (DMAP), tetramethylethylenediamine (TMEDA), and MgI2, Morita-Baylis-Hillman adducts can be obtained in good yields from various aromatic and aliphatic aldehydes and cyclic enones/enoates at room temperature.

see article for more examples



MgI2-accelerated enantioselective Morita-Baylis-Hillman reactions of cyclopentenone utilizing a chiral DMAP catalyst

A. Bugarin, B. T. Connell, Chem. Commun., 2010, 46, 2644-2646.


Key Words

Baylis-Hillman Reaction


ID: J42-Y2009-1850