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Hydroxyphosphine Ligand for Nickel-Catalyzed Cross-Coupling through Nickel/Magnesium Bimetallic Cooperation

Naohiko Yoshikai, Hirokazu Matsuda and Eiichi Nakamura*

*Department of Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: nakamurachem.s.u-tokyo.ac.jp

N. Yoshikai, H. Matsuda, E. Nakamura, J. Am. Chem. Soc., 2009, 131, 9590-9599.

DOI: 10.1021/ja903091g (free Supporting Information)


Abstract

Hydroxyphosphine ligands (PO ligands) significantly accelerate nickel-catalyzed cross-coupling reactions of Grignard reagents with unreactive aryl electrophiles such as fluorides, chlorides, carbamates and phosphates to give the corresponding cross-coupling products in good to excellent yields.

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Nickel-Catalyzed Cross-Coupling Reaction of Aryl Fluorides and Chlorides with Grignard Reagents under Nickel/Magnesium Bimetallic Cooperation

N. Yoshikai, H. Mashima, E. Nakamura, J. Am. Chem. Soc., 2005, 127, 17978-17979.


Key Words

Kumada Coupling, Biaryls


ID: J48-Y2009-2170