Domino Alkylation-Cyclization Reaction of Propargyl Bromides with Thioureas/Thiopyrimidinones: A New Facile Synthesis of 2-Aminothiazoles and 5H-Thiazolo[3,2-a]pyrimidin-5-ones
Daniele Castagnolo, Mafalda Pagano, Martina Bernardini, Maurizio Botta*
*Dipartimento Farmaco Chimico Tecnologico, Universitą degli Studi di Siena, Via A. de Gasperi 2, 53100 Siena, Italy, Email: botta.mauriziogmail.com
D. Castagnolo, M. Pagano, M. Bernardini, M. Botta, Synlett, 2009, 2093-2096.
DOI: 10.1055/s-0029-1217700
Abstract
A domino alkylation-cyclization reaction of propargyl bromides with thioureas and thiopyrimidinones allows the synthesis of 2-aminothiazoles and 5H-thiazolo[3,2-a]pyrimidin-5-ones, respectively. Domino reactions were performed under microwave irradiation leading to desired compounds in a few minutes and high yields.
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Key Words
domino reaction, thiazoles, 2-aminothiazoles, thiazolopyrimidinones, microwave synthesis, antiviral agents
ID: J60-Y2009-2270