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A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

He Huang, Hualiang Jiang, Kaixian Chen and Hong Liu*

*Graduate School, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China, Email:

H. Huang, H. Jiang, K. Chen, H. Liu, J. Org. Chem., 2009, 74, 5476-5480.

DOI: 10.1021/jo901101v (free Supporting Information)


A simple, efficient and convenient copper-catalyzed method allows the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation at room temperature.

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ID: J42-Y2009-2300