Organic Chemistry Portal

Abstracts

Search:

Pd(PPh3)4-PEG 400 Catalyzed Protocol for the Atom-Efficient Stille Cross-Coupling Reaction of Organotin with Aryl Bromides

Wen-Jun Zhou, Ke-Hu Wang and Jin-Xian Wang*

*Institute of Chemistry, Department of Chemistry, Northwest Normal University, 967 An Ning Road (E.), Lanzhou 730070, P. R. China, Email: wangjxnwnu.edu.cn

H. Huang, H. Jiang, K. Chen, H. Liu, J. Org. Chem., 2009, 74, 5599-5602.

DOI: 10.1021/jo9005206 (free Supporting Information)


Abstract

Aryl bromides (4 eq.) were coupled efficiently with organotin (1 eq.) using the tetra(triphenylphosphine)palladium/polyethylene glycol 400 catalytic system in the presence of sodium acetate as base at 100C, providing excellent yields of the corresponding substituted aryls in short reaction times.

see article for more examples



Key Words

Stille Coupling, Arylation, Alkylation


ID: J42-Y2009-2330