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Highly Chemoselective Pd-C Catalytic Hydrodechlorination Leading to the Highly Efficient N-Debenzylation of Benzylamines

Chuanjie Cheng, Jianwei Sun, Lixin Xing, Jimin Xu, Xinyan Wang* and Yuefei Hu*

*Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China, Email: wangxinyanmail.tsinghua.edu.cn, yfhmail.tsinghua.edu.cn

C. Cheng, J. Sun, L. Xing, J. Xu, X. Wang, Y. Hu, J. Org. Chem., 2009, 74, 5671-5674.

DOI: 10.1021/jo9007282


Abstract

A synergistic catalytic system based on Pd-C in the presence of 1,1,2-trichloroethane enabled the N-debenzylation of benzylamines to yield crystal amine hydrochlorides in practically quantitative yields.


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Key Words

benzylamines, debenzylation


ID: J42-Y2009-2400