Organic Chemistry Portal

Abstracts

Search:

Iridium-Catalyzed Coupling Reaction of Primary Alcohols with 1-Aryl-1-propynes Leading to Secondary Homoallylic Alcohols

Yasushi Obora*, Shintaro Hatanaka and Yasutaka Ishii

*Department of Chemistry and Materials Engineering, Faculty of Chemistry, Kansai University, Suita, Osaka 564-8680, Japan, Email: oboraipcku.kansai-u.ac.jp

Y. Obora, S. Hatanaka, Y. Ishii, Org. Lett., 2009, 11, 3510-3513.

DOI: 10.1021/ol901366q (free Supporting Information)


Abstract

An iridium-catalyzed coupling of 1-aryl-1-propynes with primary alcohols gives secondary homoallylic alcohols as products. This reaction involves an iridium-catalyzed novel catalytic transformation of 2-alkynes and primary alcohols through the formation of hydrido(π-allyl)iridium as a possible key intermediate.


see article for more examples



Key Words

Homoallylic Alcohols


ID: J54-Y2009-2440