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A Metal-Free General Procedure for Oxidation of Secondary Amines to Nitrones

Carolina Gella, Èric Ferrer, Ramon Alibés, Félíx Busqué, Pedro de March, Marta Figueredo and Josep Font

*Universitat Autònoma de Barcelona, Departament de Química, 08193 Bellaterra, Spain, Email: felix.busqueuab.es, marta.figueredouab.es

C. Gella, È. Ferrer, R. Alibés, F. Busqué, P. de March, M. Figueredo, J. Font, J. Org. Chem., 2009, 74, 6365-6367.

DOI: 10.1021/jo901108u (free Supporting Information)


Abstract

A general, efficient and metal-free protocol for the direct oxidation of secondary amines to nitrones tolerates other functional groups or existing stereogenic centers using Oxone in a biphasic basic medium as the sole oxidant.

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Key Words

Nitrones, Oxone


ID: J42-Y2009-2560