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(2-Pyridyl)acetone-Promoted Cu-Catalyzed O-Arylation of Phenols with Aryl Iodides, Bromides, and Chlorides

Qi Zhang, Deping Wang, Xianyang Wang and Ke Ding*

*Key Laboratory of Regenerative Biology and Institute of Chemical Biology, Guangzhou Institute of Biomedicine and Health, Guangzhou Science Park, Guangzhou 510663, China, Email: ding_kegibh.ac.cn

Q. Zhang, D. Wang, X. Wang, K. Ding, J. Org. Chem., 2009, 74, 7187-7190.

DOI: 10.1021/jo9012157 (free Supporting Information)


Abstract

Copper-catalyzed coupling reactions of aryl chlorides, aryl bromides, and aryl iodides with various phenols successfully proceeded in good yields under mild conditions using (2-pyridyl)acetone as ligand. This reaction displays great functional groups compatibility and excellent selectivity.

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Key Words

Ullmann Reaction


ID: J42-Y2009-2750