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Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of (E)-β,β-Disubstituted Nitroalkenes

Omid Soltani, Martin A. Ariger and Erick M. Carreira*

*Laboratorium für Organische Chemie, ETH Zürich, HCI H335, CH-8093 Zürich, Switzerland, Email: carreiraorg.chem.ethz.ch

O. Soltani, M. A. Ariger, E. M. Carreira, Org. Lett., 2009, 11, 4196-4198.

DOI: 10.1021/ol901332e (free Supporting Information)


Abstract

A mild catalytic asymmetric transfer hydrogenation of β,β-disubstituted nitroalkenes using formic acid as reductant in combination with an Ir catalyst is conducted in water at low pH and open to air to give products in good yield and selectivity.

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Transfer Hydrogenation in Water: Enantioselective, Catalytic Reduction of α-Cyano and α-Nitro Substituted Acetophenones

O. Soltani, M. A. Ariger, H. Vázquez-Villa, E. M. Carreira, Org. Lett., 2010, 12, 2893-2895.


Key Words

reduction of alkenes, formic acid, green chemistry


ID: J54-Y2009-2760