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Highly Enantioselective Alkenylation of Glyoxylate with Vinylsilane Catalyzed by Chiral Dicationic Palladium(II) Complexes

Kohsuke Aikawa, Yta Hioki and Koichi Mikami*

*Department of Applied Chemistry, Tokyo Institute of Technology, Tokyo 152-8552, Japan, Email: mikami.k.abm.titech.ac.jp

K. Aikawa, Y. Hioki, K. Mikami, J. Am. Chem. Soc., 2009, 131, 13922-13923.

DOI: 10.1021/ja906164p (free Supporting Information)



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Abstract

A chiral dicationic palladium complex-catalyzed vinylation and dienylation of glyoxylate with vinylsilanes and dienylsilanes produces highly optical active allylic alcohols. The chiral palladium catalyst is readily employed and vinylsilanes as nucleophiles are easily synthesized, storable, and air- and moisture-stable.

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Key Words

Allylic Alcohols


ID: J48-Y2009-2810