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One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates

Yu Sung Chun, Ka Yeon Ryu, Young Ok Ko, Joo Yeon Hong, Jongki Hong, Hyunik Shin and Sang-gi Lee*

*Department of Chemistry and Nano Science (BK21), Ewha Womans University, Seoul 120-750, Korea, Email: sanggiewha.ac.kr

Y. S. Chun, K. Y. Ryu, Y. O. Ko, J. Y. Hong, J. Hong, H. Shin, S.-g. Lee, J. Org. Chem., 2009, 74, 7556-7558.

DOI: 10.1021/jo901642t (free Supporting Information)


Abstract

The chemo- and regioselective reaction of the Blaise intermediate, generated in situ from Reformatsky reagent and nitrile, with propiolates affords 2-pyridone derivatives in good to excellent yields.

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Key Words

Blaise Reaction, 2-Pyridones


ID: J42-Y2009-2840