Synthesis of α-Aminonitriles through Strecker Reaction of N-Tosylaldimines Using Molecular Iodine
Biswanath Das*, Penagaluri Balasubramanyam, Maddeboina Krishnaiah, Boyapati Veeranjaneyulu, Gandolla Chinna Reddy
*Organic Chemistry Division-1, Indian Institute of Chemical
Technology, Hyderabad 500007, India, Email: biswanathdas
yahoo.com
B. Das, P. Balasubramanyam, M. Krishnaiah, B. Veerenjaneyulu, G. C. Reddy, Synthesis, 2009, 3467-3471.
DOI: 10.1055/s-0029-1216969
Abstract
The Strecker reaction of N-tosylaldimines with trimethylsilyl cyanide in the presence of catalytic amount of iodine at room temperature produces the corresponding protected α-aminonitriles in high yields.
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Key Words
Strecker Synthesis, N-tosylaldimine, trimethylsilyl cyanide, protected α-aminonitriles, iodine
ID: J66-Y2009-2920
