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A Powerful Reagent for Synthesis of Weinreb Amides Directly from Carboxylic Acids

Teng Niu, Weiming Zhang, Danfeng Huang*, Changming Xu, Haifeng Wang and Yulai Hu*

*College of Chemistry and Chemical Engineering, Northwest Normal University, 967 Anning Road (E.), Lanzhou 730070, P. R. China, Email: huylnwnu.edu.cn, huangdfnwnu.edu.cn

T. Niu, W. Zhang, D. Huang, C. Xu, H. Wang, Y. Hu, Org. Lett., 2009, 11, 4474-4477.

DOI: 10.1021/ol901886u


Abstract

P[NCH3(OCH3)]3 is a powerful reagent for conversion of aromatic and aliphatic carboxylic acids, including sterically hindered substrates, directly to Weinreb amides in excellent yields in toluene as solvent.

see article for more reactions



One-Pot Transition-Metal-Free Synthesis of Weinreb Amides Directly from Carboxylic Acids

T. Niu, K.-H. Wang, D. Huang, C. Xu, Y, Su, Y. Hu, Y. Fu, Synthesis, 2014, 46, 320-330.


Key Words

Weinreb Amides


ID: J54-Y2009-2950