Pd(II)-Catalyzed Hydroxylation of Arenes with 1 atm of O2 or Air
Yang-Hui Zhang and Jin-Quan Yu*
*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Email: yu200scripps.edu
Y.-H. Zhang, J.-Q. Yu, J. Am. Chem. Soc., 2009, 131, 14654-14655.
DOI: 10.1021/ja907198n (free Supporting Information)
Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under an athmospheric pressure of oxygen or air is achieved under nonacidic conditions. Labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.
see article for more examples