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Pd(II)-Catalyzed Hydroxylation of Arenes with 1 atm of O2 or Air

Yang-Hui Zhang and Jin-Quan Yu*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Email: yu200scripps.edu

Y.-H. Zhang, J.-Q. Yu, J. Am. Chem. Soc., 2009, 131, 14654-14655.

DOI: 10.1021/ja907198n (free Supporting Information)


Abstract

Pd(II)-catalyzed ortho-hydroxylation of variously substituted benzoic acids under an athmospheric pressure of oxygen or air is achieved under nonacidic conditions. Labeling studies support a direct oxygenation of aryl C-H bonds with molecular oxygen.


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Key Words

Hydroxylation, Oxygen, Benzoquinone


ID: J48-Y2009-2960