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Cross-Coupling of Alkenyl/Aryl Carboxylates with Grignard Reagent via Fe-Catalyzed C-O Bond Activation

Bi-Jie Li, Li Xu, Zhen-Hua Wu, Bing-Tao Guan, Chang-Liang Sun, Bi-Qin Wang and Zhang-Jie Shi*

*Beijing National Laboratory of Molecular Sciences (BNLMS), College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, China, Email: zshipku.edu.cn

B.-J. Li, L. Xu, Z.-H. Wu, B.-T. Guan, C.-L. Sun, B.-Q. Wang, Z.-J. Shi, J. Am. Chem. Soc., 2009, 131, 14656-14657.

DOI: 10.1021/ja907281f (free Supporting Information)


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Abstract

An efficient iron-catalyzed cross-coupling of primary alkyl Grignard reagents allows the use of alkenyl and aryl pivalates as electrophiles under mild conditions. The combination of an inexpensive and stable carboxylate electrophile and an iron catalyst would generate ample advantages.

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Key Words

Olefination, Cyclohexenes


ID: J48-Y2009-3010