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Heteroaromatic Sulfonates and Phosphates as Electrophiles in Iron-Catalyzed Cross-Couplings

Thomas M. Gøgsig, Anders T. Lindhardt and Troels Skrydstrup*

*Department of Chemistry and the Interdisciplinary Nanoscience Center, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark, Email: tschem.au.dk

T. M. Gøgsig, A. T. Lindhardt, T. Skrydstrup, Org. Lett., 2009, 11, 4886-4888.

DOI: 10.1021/ol901975u (free Supporting Information)


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Abstract

Heteroaromatic tosylates and phosphates are suitable electrophiles in iron-catalyzed cross-coupling reactions with alkyl Grignard reagents. These reactions are performed at low temperature allowing good functional group tolerance with full conversion within minutes.

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Key Words

Pyridines, Quinolines


ID: J54-Y2009-3130