A simple and highly efficient synthesis of β-amino-α,β-unsaturated ester via sonochemical Blaise reaction
Adam Shih-Yuan Lee* and Rae-Yi Cheng
*Department of Chemistry, Tamkang University, Taipei, Taiwan 251, Email: adamleemail.tku.edu.tw
A. S.-Y. Lee, R.-Y. Cheng, Tetrahedron Lett., 1997, 38, 443-446.
DOI: 10.1021/jo901765s (free Supporting Information)
β-Amino-α,β-unsaturated esters are produced by a sonochemical Blaise reaction of nitriles, zinc powder, zinc oxide and ethyl bromoacetate in THF in a commercial ultrasonic cleaning bath.
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