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Highly Regio- and Stereoselective Addition of 1,3-Diketones to Internal Alkynes Catalyzed by Cationic Iridium Complex

Gen Onodera, Minoru Kato, Ryo Kawano, Yuri Kometani and Ryo Takeuchi*

*Department of Chemistry and Biological Science, Aoyama Gakuin University, 5-10-1 Fuchinobe, Sagamihara, Kanagawa 229-8558, Japan, Email: takeuchichem.aoyama.ac.jp

G. Onodera, M. Kato, R. Kawano, Y. Kometani, R. Takeuchi, Org. Lett., 2009, 11, 5038-5041.

DOI: 10.1021/ol9020095

Abstract

A regio- and stereoselective addition of 1,3-diketones to unfunctionalized internal alkynes under neutral conditions is achieved by using [Ir(cod)2]SbF6 as a catalyst.

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Key Words

Active Methylenes

ID: J54-Y2009-3270