The Use of Calcium Carbide in the Synthesis of 1-Monosubstituted Aryl 1,2,3-Triazole via Click Chemistry
Yubo Jiang, Chunxiang Kuang*, Qing Yang
*Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China, Email: kuangcxtongji.edu.cn
Y. Jiang, C. Kuang, Q. Yang, Synlett, 2009, 3163-3166.
DOI: 10.1055/s-0029-1218346 (free Supporting Information)
see article for more reactions
The synthesis of 1-monosubstituted aryl 1,2,3-triazoles was achieved in good yields using calcium carbide as a source of acetylene. The copper-catalyzed 1,3-dipolar cycloaddition reactions were carried out without nitrogen protection and in a MeCN-H2O mixture.
see article for more examples
M. Xu, C. Kuang, Z. Wang, Q. Yang, Y. Jiang, Synthesis, 2011, 223-228.
W. Zhang, C. Kuang, Q. Yang, Synthesis, 2010, 283-287.