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The Use of Calcium Carbide in the Synthesis of 1-Monosubstituted Aryl 1,2,3-Triazole via Click Chemistry

Yubo Jiang, Chunxiang Kuang*, Qing Yang

*Department of Chemistry, Tongji University, Siping Road 1239, Shanghai 200092, P. R. of China, Email: kuangcxtongji.edu.cn

Y. Jiang, C. Kuang, Q. Yang, Synlett, 2009, 3163-3166.

DOI: 10.1055/s-0029-1218346 (free Supporting Information)



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Abstract

The synthesis of 1-monosubstituted aryl 1,2,3-triazoles was achieved in good yields using calcium carbide as a source of acetylene. The copper-catalyzed 1,3-dipolar cycloaddition reactions were carried out without nitrogen protection and in a MeCN-H2O mixture.

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A Novel Approach to 1-Monosubstituted 1,2,3-Triazoles by a Click Cycloaddition/Decarboxylation Process

M. Xu, C. Kuang, Z. Wang, Q. Yang, Y. Jiang, Synthesis, 2011, 223-228.

Palladium-Catalyzed One-Pot Synthesis of 4-Aryl-1H-1,2,3-triazoles from anti-3-Aryl-2,3-dibromopropanoic Acids and Sodium Azide

W. Zhang, C. Kuang, Q. Yang, Synthesis, 2010, 283-287.


Key Words

calcium carbide, 1,2,3-triazoles, copper-catalyzed, click chemistry


ID: J60-Y2009-3480