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Rhodium-Catalyzed Enantioselective Cyclopropanation of Olefins with N-Sulfonyl 1,2,3-Triazoles

Stepan Chuprakov, Sen Wai Kwok, Li Zhang, Lukas Lercher and Valery V. Fokin*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Email: fokinscripps.edu

S. Chuprakov, S. W. Kwok, L. Zhang, L. Lercher, V. V. Fokin, J. Am. Chem. Soc., 2009, 131, 18034-18035.

DOI: 10.1021/ja908075u (free Supporting Information)



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Abstract

N-Sulfonyl 1,2,3-triazoles readily form rhodium(II) azavinyl carbenes, which react with olefins to produce cyclopropane derivatives in high yield with excellent diastereo- and enantioselectivity.


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Key Words

Cyclopropanes


ID: J48-Y2009-3540