Lewis Acid Catalyzed Indole Synthesis via Intramolecular Nucleophilic Attack of Phenyldiazoacetates to Iminium Ions
Lei Zhou and Michael P. Doyle*
*Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, Email: mdoyle3umd.edu
L. Zhou, M. P. Doyle, J. Org. Chem., 2009, 74, 9222-9224.
DOI: 10.1021/jo902089e (free Supporting Information)
Lewis acids catalyze the cyclization of methyl phenyldiazoacetates with an ortho-imino group, prepared from o-aminophenylacetic acid, to give 2,3-substituted indoles in quantitative yields.
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