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Microwave Irradiation as an Effective Means of Synthesizing Unsubstituted N-Linked 1,2,3-Triazoles from Vinyl Acetate and Azides

Signe Grann Hansen, Henrik Helligsų Jensen*

*Department of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark, Email: hhjchem.au.dk

S. G. Hansen, H. H. Jensen, Synlett, 2009, 3275-3278.

DOI: 10.1055/s-0029-1218366 (free Supporting Information)


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Abstract

1-Monosubstituted 1,2,3-triazoles have been prepared by a reaction of azides with vinyl acetate under microwave irradiation. Additionally, a microwave-assisted, two-step, one-pot procedure from halides involving azide substitution using TBAN3 in diethyl ether, followed by reaction with vinyl acetate, has effectively been employed.

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Key Words

1,2,3-triazoles, vinyl acetate, microwave synthesis, one-pot reaction, Huisgen 1,3-dipolar cycloaddition, Click Chemistry


ID: J60-Y2009-3590