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The Highly Efficient 1,4-Addition of TMSCN to Aromatic Enones Catalyzed by CsF with Water as the Additive

Jingya Yang, Yinxian Wang, Shaoxiang Wu, Fu-Xue Chen*

*Department of Applied Chemistry, School of Chemical Engineering & the Environment, Beijing Institute of Technology, No. 5 South Zhongguancun Street, Haidian District, Beijing 100081, P. R. of China, Email: fuxue.chenbit.edu.cn

J. Yang, Y. Wang, S. Wu, F.-X. Chen, Synlett, 2009, 3365-3367.

DOI: 10.1055/s-0029-1218376 (free Supporting Information)


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Abstract

An efficient 1,4-addition of TMSCN to aromatic enones has been achieved in excellent yields in the presence of CsF as catalyst and H2O as an additive in refluxing dioxane.

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Highly Efficient Cs2CO3-Catalyzed 1,4-Addition of Me3SiCN to Enones with Water as the Additive

J. Yang, Y. Shen, F.-X. Chen, Synthesis, 2010, 1325-1333.


Key Words

1,4-addition reaction, enones, nitriles, regioselectivity, CsF


ID: J60-Y2009-3650